RHAMM-R3 peptide vaccination in patients with acute myeloid leukemia, myelodysplastic syndrome and multiple myeloma elicits im

نویسندگان

  • Michael Schmitt
  • Anita Schmitt
  • Markus T. Rojewski
  • Jinfei Chen
  • Krzysztof Giannopoulos
  • Fei Fei
  • Yingzhe Yu
  • Marlies Götz
  • Marta Heyduk
  • Gerd Ritter
  • Daniel E. Speiser
  • Sacha Gnjatic
  • Philippe Guillaume
  • Mark Ringhoffer
  • Richard F. Schlenk
  • Peter Liebisch
  • Donald Bunjes
  • Hiroshi Shiku
  • Hartmut Dohner
  • Jochen Greiner
چکیده

Michael Schmitt, Anita Schmitt, Markus T. Rojewski, Jinfei Chen, Krzysztof Giannopoulos, Fei Fei, Yingzhe Yu, Marlies Götz, Marta Heyduk, Gerd Ritter, Daniel E. Speiser, Sacha Gnjatic, Philippe Guillaume, Mark Ringhoffer, Richard F. Schlenk, Peter Liebisch, Donald Bunjes, Hiroshi Shiku, Hartmut Dohner, and Jochen Greiner Department of Internal Medicine III, University of Ulm, Robert-Koch-Str. 8, 89081 Ulm, Germany; Institute for Transfusion Medicine, University of Ulm and Institute for Clinical Transfusion Medicine and Immunogenetics Ulm gemeinnützige GmbH, Helmholtzstr. 10, 89081 Ulm, Germany; Lublin Medical University, Dept. of Clinical Immunology, Raclawickie 1, 20-950 Lublin, Poland; Ludwig Institute for Cancer Research (LICR) New York Branch, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY10021, USA; Division of Clinical Onco-Immunology, LICR, Hôpital Orthopédique, Niveau 5 Est, Av. Pierre-Decker 4, CH-1005 Lausanne, Switzerland; LICR, Lausanne Branch, University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland; Mie University Medical School, 2-174 Edo-bashi, 514 Tsu, Japan;

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RHAMM-R3 peptide vaccination in patients with acute myeloid leukemia, myelodysplastic syndrome, and multiple myeloma elicits immunologic and clinical responses.

The receptor for hyaluronic acid-mediated motility (RHAMM) is an antigen eliciting both humoral and cellular immune responses in patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and multiple myeloma (MM). We initiated a phase 1 clinical trial vaccinating 10 patients with R3 (ILSLELMKL), a highly immunogenic CD8(+) T-cell epitope peptide derived from RHAMM. In 7 of 10 ...

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High-dose RHAMM-R3 peptide vaccination for patients with acute myeloid leukemia, myelodysplastic syndrome and multiple myeloma.

BACKGROUND Recently, we demonstrated immunological and clinical responses to a RHAMM-R3 peptide vaccine in patients with acute myeloid leukemia, myelodysplastic syndrome and multiple myeloma. To improve the outcome of the vaccine, a second cohort was vaccinated with a higher dose of 1,000 microg peptide. DESIGN AND METHODS Nine patients received four vaccinations subcutaneously at a biweekly ...

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High dose RHAMM-R3 peptide vaccination for patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) and multiple myeloma (MM)

Background: Recently, we demonstrated immunological and clinical responses to a RHAMM-R3 peptide vaccine in patients with acute myeloid leukemia, myelodysplastic syndrome (MDS) and multiple myeloma (MM). To improve the outcome of the vaccine, a second cohort was vaccinated with a higher dose of 1,000μg peptide. Design and Methods: Nine patients received four vaccinations subcutaneously at a biw...

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IMMUNOBIOLOGY RHAMM-R3 peptide vaccination in patients with acute myeloid leukemia, myelodysplastic syndrome, and multiple myeloma elicits immunologic and clinical responses

1Department of Internal Medicine III, University of Ulm, Ulm, Germany; 2Institute for Transfusion Medicine, University of Ulm and Institute for Clinical Transfusion Medicine and Immunogenetics Ulm Gemeinnützige gGmbH, Ulm, Germany; 3Lublin Medical University, Department of Clinical Immunology, Lublin, Poland; 4Ludwig Institute for Cancer Research (LICR) New York Branch, Memorial Sloan-Kettering...

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Identification and characterization of epitopes of the receptor for hyaluronic acid-mediated motility (RHAMM/CD168) recognized by CD8+ T cells of HLA-A2-positive patients with acute myeloid leukemia.

The receptor for hyaluronic acid-mediated motility (RHAMM/CD168) has been described as a leukemia-associated antigen. To define T-cell epitopes of RHAMM/CD168 toward specific immunotherapies for acute myeloid leukemia (AML), 10 potential HLA-A2-binding RHAMM/CD168 peptides (R1 to R10) were synthesized based on computer algorithms and screened by enzyme-linked immunospot (ELISPOT) analysis using...

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تاریخ انتشار 2007